Bio

Contact Information:

UIC – Department of Chemical Engineering, 810 S. Clinton, Chicago, IL 60607

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Postdoctoral
Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 2001

Ph.D.
Pharmaceutics, Purdue University, West Lafayette, IN, 1999

BS
Bioengineering, Purdue University, West Lafayette, IN, 1994

We are interested in designing polymers that interact with cells to elicit a desired biologic response. We currently have projects in the areas of cellular differentiation and cancer treatment. By utilizing and mimicking biologic interactions into synthetic polymers, the desired properties of the polymer can be exploited. The biologic motifs allow the cells or tissue to respond in a natural manner to the polymer resulting in more natural regeneration, regrowth, or cellular death.

Awards and Honors:

2014, Hans W. Vahlteich Scholar, University of Illinois at Chicago, College of Pharmacy

2006, Young Investigator Award, Society for Biomaterials

2006, Hans W. Vahlteich Scholar, University of Illinois at Chicago, College of Pharmacy

2002, New Investigator Award, American Association of Colleges of Pharmacy

Patents and Intellectual Property:

Gemeinhart RA, Buhrman JS, Rayahin JE. Hydrogels for Delivery of Therapeutic Polypeptides, Patent Application Pending, US2014/405,701 (April 22, 2015)

Gemeinhart RA. Superporous Hydrogel with Cells Encapsulated Therein and Method for Producing the Same. US 8,414,879B2 (April 9, 2013)

Gemeinhart RA, Tauro JR. Composition and Method for Providing Localized Delivery of a Therapeutic Agent. US 7,943,569 (May 17, 2011)

Cho MR, Kadakia A, Djilian A, Gemeinhart RA. Hybrid Superporous Hydrogel Scaffold for Cornea Regeneration. Patent Application Pending, 20100080840A1 (April 1, 2010)

Patents and Intellectual Property:

  1. Gemeinhart RA, Buhrman JS, Rayahin JE. Hydrogels for Delivery of Therapeutic Polypeptides, Patent Application Pending, US2014/405,701 (April 22, 2015).
  2. Gemeinhart RA. Superporous Hydrogel with Cells Encapsulated Therein and Method for Producing the Same. US 8,414,879B2 (April 9, 2013).
  3. Gemeinhart RA, Tauro JR. Composition and Method for Providing Localized Delivery of a Therapeutic Agent. US 7,943,569 (May 17, 2011).
  4. Cho MR, Kadakia A, Djilian A, Gemeinhart RA. Hybrid Superporous Hydrogel Scaffold for Cornea Regeneration. Patent Application Pending, 20100080840A1 (April 1, 2010).

Journal Articles:

  1. Zhang Y, Buhrman JS, Liu Y, Rayahin JE, Gemeinhart RA. “Reducible Micelleplexes are Stable Systems for Anti-miRNA Delivery in Cerebrospinal Fluid”. Molecular Pharmaceutics. 2016;13(6):1791-1799. doi:10.1021/acs.molpharmaceut.5b00933.
  2. Jaishankar D, Buhrman JS, Valyi-Nagy T, Gemeinhart RA, Shukla D. “Extended release of an anti-heparan sulfate peptide from a contact lens suppresses corneal Herpes Simplex Virus-1 (HSV-1) infection”.Investigative Ophthalmology and Visual Science. 2016;57(1):169-180. doi: 10.1167/iovs.15-18365.
  3. Lu Y, Chen Y, Gemeinhart RA, Wu W, Li T. “Developing nanocrystals for cancer treatment”. Nanomedicine. 2015;(10(16)):2537-2552. doi:10.2217/nnm.15.73.
  4. Rayahin JE, Buhrman JS, Zhang Y, Koh TJ, Gemeinhart RA. “High and low molecular weight hyaluronic acid differentially influence macrophage activation”. ACS Biomaterials Science and Engineering. 2015;(1(7)):481-493. doi:10.1021/acsbiomaterials.5b00181.
  5. Zhang Y, Liu Y, Sen S, Král P, Gemeinhart RA. “Charged group surface accessibility determines micelleplexes formation and cellular interaction”. Nanoscale. 2015;(7(17)):7559-7564. doi:10.1039/c5nr00095e.
  6. Rayahin JE, Buhrman JS, Gemeinhart RA. “Melittin-glutathione S-transferase fusion protein exhibits anti-inflammatory properties and minimal toxicity”. European Journal of Pharmaceutical Sciences. 2014;(65):112-121. doi:10.1016/j.ejps.2014.09.012.
  7. Zhang Y, Köllmer M, Buhrman JS, Tang MY, Gemeinhart RA. “Arginine-rich, cell penetrating peptide-anti-microRNA complexes decrease glioblastoma migration potential”. Peptides. 2014;(58(1)):83-90. doi:10.1016/j.peptides.2014.06.008.
  8. Hollis CP, Weiss HL, Evers BM, Gemeinhart RA, Li T. “In vivo investigation of hybrid paclitaxel nanocrystals with dual fluorescent probes for cancer theranostics”. Pharmaceutical research. 2014;(31(6)):1450-1459. doi:10.1007/s11095-013-1048-x.
  9. Sharma V, Köllmer M, Szymusiak M, Nitsche LC, Gemeinhart RA, Liu Y. “Toroidal-spiral particles for codelivery of anti-VEGFR-2 antibody and irinotecan: a potential implant to hinder recurrence of glioblastoma multiforme”. Biomacromolecules. 2014;(15(3)):756-762. doi:10.1021/bm401550r.
  10. Zhang H, Wang X, Dai W, Gemeinhart RA, Zhang Q, Li T. “Pharmacokinetics and treatment efficacy of camptothecin nanocrystals on lung metastasis”. Molecular Pharmaceutics. 2014;(11(1)):226-233. doi:10.1021/mp4004018.
  11. Zellander A, Zhao C, Kotecha M, Gemeinhart RA, Wardlow M, Abiade J, Cho M. “Characterization of pore structure in biologically functional poly(2-hydroxyethyl methacrylate)-poly(ethylene glycol) diacrylate (PHEMA-PEGDA)”. PLoS ONE. 2014;(9(5)):e96709. doi:10.1371/journal.pone.0096709.
  12. Zhang Y, Wang Z, Gemeinhart RA. “Progress in microRNA delivery”. Journal of Controlled Release. 2013;(172(3)):962-974. doi:10.1016/j.jconrel.2013.09.015.
  13. Köllmer M, Popescu C, Manda P, Zhou L, Gemeinhart RA. “Stability of benzocaine formulated in commercial oral disintegrating tablet platforms”. AAPS PharmSciTech. 2013;(14(4)):1333-1340. doi:10.1208/s12249-013-0015-5.
  14. Hollis CP, Weiss HL, Leggas M, Evers BM, Gemeinhart RA, Li T. “Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery”. Journal of Controlled Release. 2013;(172(1)):12-21. doi:10.1016/j.jconrel.2013.06.039.
  15. Buhrman JS, Cook L, Rayahin JE, Federle M, Gemeinhart RA. “Proteolytically activated anti-bacterial hydrogel microspheres”. Journal of Controlled Release. 2013;(171(3)):2882-2895. doi:10.1016/j.jconrel.2013.06.023.
  16. Buhrman JS, Rayahin JE, Cook L, Federle M, Gemeinhart RA. “Active, soluble recombinant melittin purified by extracting insoluble lysate of Escherichia coli without denaturation”. Biotechnology Progress. 2013;(29(5)):1150-1157. doi:10.1002/btpr.1784.
  17. Zellander A, Gemeinhart RA, Djalilian A, Makhsous M, Sun S, Cho M. “Designing a gas foamed scaffold for keratoprosthesis”. Materials Science & Engineering. C, Materials for Biological Applications. 2013;(33(6)):3396-3403. doi:10.1016/j.msec.2013.04.025.
  18. Köllmer M, Buhrman JS, Zhang Y, Gemeinhart RA. “Markers are shared between adipogenic and osteogenic differentiated mesenchymal stem cells”. Journal of Developmental Biology and Tissue Engineering. 2013;(5(2)):18-25. doi:10.5897/JDBTE2013.0065.
  19. Buhrman JS, Rayahin JE, Köllmer M, Gemeinhart RA. “In-house preparation of hydrogels for batch affinity purification of glutathione S-transferase tagged recombinant proteins”. BMC Biotechnology. 2012;(12):63. doi:10.1186/1472-6750-12-63.
  20. Ross AE, Tang MY, Gemeinhart RA. “Effects of molecular weight and loading on matrix metalloproteinase-2 mediated release from poly(ethylene glycol) diacrylate hydrogels”. The AAPS Journal. 2012;(14(3)):482-490. doi:10.1208/s12248-012-9356-3.
  21. Zhang Y, Gemeinhart RA. “Improving matrix metalloproteinase-2 specific response of a hydrogel system using electrophoresis”. International Journal of Pharmaceutics. 2012;(429(1-2)):31-37. doi:10.1016/j.ijpharm.2012.03.012.
  22. Shafiq MA, Gemeinhart RA, Yue BY, Djalilian AR. “Decellularized human cornea for reconstructing the corneal epithelium and anterior stroma”. Tissue Engineering. Part C, Methods. 2012;(18(5)):340-348. doi:10.1089/ten.TEC.2011.0072.
  23. Köllmer M, Keskar V, Hauk TG, Collins JM, Russell B, Gemeinhart RA. “Stem cell-derived extracellular matrix enables survival and multilineage differentiation within superporous hydrogels”. Biomacromolecules. 2012;(13(4)):963-973. doi:10.1021/bm300332w.
  24. Desai ES, Tang MY, Ross AE, Gemeinhart RA. “Critical factors affecting cell encapsulation in superporous hydrogels”. Biomedical Materials. 2012;(7(2)):024108. doi:10.1088/1748-6041/7/2/024108.
  25. Rayahin JE, Buhrman JS, Gemeinhart RA. “Hybrid nanocrystals: University of Kentucky US20060280680A1”.Expert Opinion on Therapeutic Patents. 2012;(22(3)):34134-8. doi:10.1517/13543776.2012.665877.
  26. Zhao R, Hollis CP, Zhang H, Sun L, Gemeinhart RA, Li T. “Hybrid nanocrystals: achieving concurrent therapeutic and bioimaging functionalities toward solid tumors”. Molecular Pharmaceutics. 2011;(8(5)):1985-1991. doi:10.1021/mp200154k.
  27. Bae M, Gemeinhart RA, Divan R, Suthar KJ, Mancini DC. “Fabrication of poly(ethylene glycol) hydrogel structures for pharmaceutical applications using electron beam and optical lithography”. Journal of Vacuum Science & Technology. B, Microelectronics and Nanometer Structures : Processing, Measurement, and Phenomena. 2010;(28(6)):C6P24-C6P29. doi:10.1116/1.3517716.
  28. Vartak DG, Lee BS, Gemeinhart RA. “In vitro evaluation of functional interaction of integrin alphavbeta3 and matrix metalloprotease-2”. Molecular Pharmaceutics. 2009;(6(6)):1856-1867. doi:10.1021/mp900152t.
  29. Keskar V, Gandhi M, Gemeinhart EJ, Gemeinhart RA. “Initial evaluation of vascular ingrowth into superporous hydrogels”. Journal of Tissue Engineering and Regenerative Medicine. 2009;3(6):486-490. doi:10.1002/term.183.
  30. Keskar V, Marion NW, Mao JJ, Gemeinhart RA. “In vitro evaluation of macroporous hydrogels to facilitate stem cell infiltration, growth, and mineralization”. Tissue Engineering. Part A. 2009;(15(7)):1695-1707. doi:10.1089/ten.tea.2008.0238.
  31. Gandhi M, Srikar R, Yarin AL, Megaridis CM, Gemeinhart RA. “Mechanistic examination of protein release from polymer nanofibers”. Molecular Pharmaceutics. 2009;(6(2)):641-647. doi:10.1021/mp800160p.
  32. Tauro JR, Lee BS, Lateef SS, Gemeinhart RA. “Matrix metalloprotease selective peptide substrates cleavage within hydrogel matrices for cancer chemotherapy activation”. Peptides. 2008;(29(11)):1965-1973. doi:10.1016/j.peptides.2008.06.021.
  33. Guo C, Gemeinhart RA. “Understanding the adsorption mechanism of chitosan onto poly(lactide-co-glycolide) particles”. European Journal of Pharmaceutics and Biopharmaceutics. 2008;(70(2)):597-604. doi:10.1016/j.ejpb.2008.06.008.
  34. Kadakia A, Keskar V, Titushkin I, Djalilian A, Gemeinhart RA, Cho M. “Hybrid superporous scaffolds: an application for cornea tissue engineering”. Critical reviews in biomedical engineering. 2008;(36(5-6)):441-471. doi:10.1615/CritRevBiomedEng.v36.i5-6.50.
  35. Chaterji S, Gemeinhart RA. “Enhanced osteoblast-like cell adhesion and proliferation using sulfonate-bearing polymeric scaffolds”. Journal of Biomedical Materials Research. Part A. 2007;(83(4)):990-998. doi:10.1002/jbm.a.31283.
  36. Vartak DG, Gemeinhart RA. “Matrix metalloproteases: underutilized targets for drug delivery”. Journal of Drug Targeting. 2007;(15(1)):1-20. doi:10.1080/10611860600968967 .
  37. Keskar V, Mohanty PS, Gemeinhart EJ, Gemeinhart RA. “Cervical cancer treatment with a locally insertable controlled release delivery system”. Journal of Controlled Release. 2006;(115(3)):280-288. doi:10.1016/j.jconrel.2006.08.014.
  38. Gemeinhart RA, Bare CM, Haasch RT, Gemeinhart EJ. “Osteoblast-like cell attachment to and calcification of novel phosphonate-containing polymeric substrates”. Journal of biomedical materials research. Part A. 2006;(78(3)):433-440. doi:10.1002/jbm.a.30788.
  39. Muni NJ, Qian H, Qtaishat NM, Gemeinhart RA, Pepperberg DR. “Activation of membrane receptors by neurotransmitter released from temperature-sensitive hydrogels”. Journal of Neuroscience Methods. 2006;(151(2)):97-105. doi:10.1016/j.jneumeth.2005.06.029.
  40. Tauro JR, Gemeinhart RA. “Extracellular protease activation of chemotherapeutics from hydrogel matrices: a new paradigm for local chemotherapy”. Molecular Pharmaceutics. 2005;(2(5)):435-438. doi:10.1021/mp050028n.
  41. Tauro JR, Gemeinhart RA. “Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes”. Bioconjugate Chemistry. 2005;16(5):1133-9. doi:10.1021/bc0501303.
  42. Yan X, Gemeinhart RA. “Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles”.Journal of Controlled Release. 2005;(106(1-2)):198-208. doi:10.1016/j.jconrel.2005.05.005.
  43. Tan J, Gemeinhart RA, Ma M, Saltzman WM. “Improved cell adhesion and proliferation on synthetic phosphonic acid-containing hydrogels”. Biomaterials. 2005;(26(17)):3663-3671. doi:10.1016/j.biomaterials.2004.09.053.
  44. Gemeinhart RA, Luo D, Saltzman WM. “Cellular fate of a modular DNA delivery system mediated by silica nanoparticles”. Biotechnology Progress. 2005;(21(2)):532-537. doi:10.1021/bp049648w.
  45. Tauro JR, Gemeinhart RA. “Development of amine-containing polymeric particles”. Journal of Biomaterials Science. Polymer Edition. 2005;(16(10)):1233-1244. doi:10.1163/156856205774269539.
  46. Kang CE, Gemeinhart EJ, Gemeinhart RA. “Cellular alignment by grafted adhesion peptide surface density gradients”. Journal of Biomedical Materials Research. Part A. 2004;(71(3)):403-411. doi:10.1002/jbm.a.30137.
  47. Guo C, Gemeinhart RA. “Assessment of a modular transfection system based upon cellular localization of DNA”. Molecular Pharmaceutics. 2004;(1(4)):309-316. doi:10.1021/mp049969a.
  48. Gemeinhart RA, Park H, Park K. “Effect of compression on fast swelling of poly(acrylamide-co-acrylic acid) superporous hydrogels”. Journal of Biomedical Materials Research. 2001;55(1):54-62. doi:10.1002/1097-4636(200104)55:1%3C54::AID-JBM80%3E3.0.CO;2-Y.
  49. Gemeinhart RA, Chen J, Park H, Park K. “pH-sensitivity of fast responsive superporous hydrogels”. Journal of Biomaterials Science-Polymer Edition. 2000;11(12):1371-1380. doi:10.1163/156856200744390.
  50. Gemeinhart RA, Park H, Park K. “Pore structure of superporous hydrogels”. Polymers for Advanced Technologies. 2000;11(8-12):617-625. doi:10.1002/1099-1581(200008/12)11:8/12%3C617::AID-PAT12%3E3.0.CO;2-L.
  51. Park K, Gemeinhart RA, Park H. “Movement of fibrinogen receptors on the ventral membrane of spreading platelets”. Biomaterials. 1998;19(4-5):387-95. doi:10.1016/S0142-9612(97)00111-7.

Book Chapters: 

  1. Zamiri C, Gemeinhart RA. “Drug Delivery Systems for Pulmonary Delivery of Therapeutic Biomacromolecules”. Groves, MJ. Pharmaceutical Biotechnology. Boca Raton, FL: CRC Press; 2005: 255-277
  2. Gemeinhart RA. “Polymeric Systems for Oral Protein and Peptide Delivery”. Groves, MJ. Pharmaceutical Biotechnology. Boca Raton, FL: CRC Press; 2005: 279-302
  3. Gemeinhart RA, Guo C. “Fast Swelling Hydrogels”. Yui N, Mrsny R, Park K. Reflexive polymers and hydrogels: Understanding and designing fast-responsive polymeric systems. Boca Raton, FL: CRC Press; 2004: 245-257