Bio

Contact Information:

UIC – Department of Chemical Engineering, 810 S. Clinton, Chicago, IL 60607

Lab Website: EMR Laboratory

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Ph.D., Chemical Engineering 

University of Cambridge, 2007 

MS, Chemical Engineering

University of Cambridge 

Bachelor’s degree in Chemical Engineering 

University of Cambridge 

Our research group brings computational tools together with experimental magnetic resonance to elucidate the interplay of dynamic structures, transport, and molecular transformations in complex systems. We aim to derive a multi-scale understanding of coupled transport processes in multi-component, multiphase systems. Our current emphasis is on biomedical challenges.

†senior author(s) *co-first authors #undergraduate

  1. Ayee M.A. A. , LeMaster E., Shentu T.P., Singh D., Subbaiah P.V., Berdyshev E., Bronova I., Cho M., Akpa B.S. and Levitan I. Molecular-scale biophysical modulation of an endothelial membrane by OxPAPC. Submitted.
  2. Liang Y., Chen W., Akpa B.S., Neuberger T., Webb A.G., Magin R.L.† Using spectral and cumulative spectral entropy to classify anomalous diffusion in Sephadex gels. Submitted.
  3. Feinstein D.L., Akpa B.S., Ayee M. A., Braun D., Brodsky S.V., Gidalevitz D, Hauck Z., Kalinin S., Kowal K., Kuzmenko I., Lis K., Marangoni N., Martynowycz M.W., Rubinstein I., Ware K., van Breeman R., Weinberg G.L. The emerging threat of superwarfarins: detection, mechanisms of damage, and potential treatments. Available online (2016).
  4. Ayee M.A.A., Roth C.#, and Akpa B. S. Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study. Journal of Colloid and Interface Science. 468:227-237 (2016).
  5. Fettiplace M.R., Akpa B.S., Rubinstein I., and Weinberg G.L. Confusions about infusion: Rational volume guidelines for intravenous lipid emulsion during treatment of oral overdose. Annals of Emergency Medicine. 66(2):185-188 (2015)
  6. Fettiplace M.R., Lis K., Ripper R., Kowal K., Pichurko A., Vitello D., Schwartz D., Rubinstein I., Akpa B.S. , and Weinberg G.L.  Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsionJournal of Controlled Release. 198:62-70 (2015)COVER STORY with editorial
  7. Fettiplace M.R. *, Akpa B.S.*, Ripper R., Zider B., Lang J., Rubinstein I., Weinberg G.L. Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology. 120(4):915-925 (2014). Corresponding editorial
  8. Kuo I., Akpa B.S. Validity of the lipid sink as a mechanism for reversal of local anesthetic systemic toxicity: A physiologically based pharmacokinetic model study. Anesthesiology. 118(6):1350-1361 (2013). 
  9. Akpa B.S., D’Agostino C., Gladden L.F., Hindle K., Manyar H., McGregor J., Li R., Neurock M., Sinha N., Stitt E.H., Weber D., Zeitler J.A., Rooney D.W. Solvent effects in the hydrogenation of 2-butanone. Journal of Catalysis. 289:30-41 (2012).
  10. Bern S., Akpa B.S., Kuo I., Weinberg G. Lipid Resuscitation: A Life-saving Antidote for Local Anesthetic ToxicityCurrent Pharmaceutical Biotechnology. 12(2):313-319 (2011).
  11. Magin R.L., Akpa B.S., Neuberger T., Webb A.G. Fractional order analysis of Sephadex gel structures: NMR measurements reflecting anomalous diffusionCommunications in Nonlinear Science and Numerical Simulation. 16(12):4581-4587 (2011).
  12. Parkar N.S., Akpa B.S., Nitsche L.C., Wedgewood L.E., Sverdlov M.S., Chaga O., and Minshall R.D. Vesicle Formation and Endocytosis: Function, Machinery, Mechanisms, and ModelingAntioxidants & Redox Signaling. 11(6):1301-1312 (2009).
  13. Graf von der Schulenburg D.A., Akpa B.S., Gladden L.F., Johns M.L. Non-invasive mass transfer measurements in complex biofilm-coated structuresBiotechnology and Bioengineering. 101(3):602-608 (2008).
  14. Sullivan S.P., Akpa B.S., Matthews S.M., Fisher A.C., Gladden L.F., Johns M.L. Simulation of miscible diffusive mixing in microchannels. Sensors and Actuators B. 123:1142-1152 (2007).
  15. Akpa B.S., Matthews S.M., Sederman A.J., Yunus K., Fisher A.C., Gladden L.F. Study of miscible and immiscible flow in a microfluidic device using magnetic resonance imaging. Analytical Chemistry. 79:6128-6134 (2007).
  16. Akpa B.S., Holland D.J., Sederman A.J., Johns M.L., Gladden L.F. Enhanced 13C PFG-NMR for the study of dispersion in porous media. Journal of Magnetic Resonance. 186:160-165 (2007).
  17. Gladden L.F., Akpa B.S., Anadon L.D., Heras J.J., Holland D.J., Mantle M.D., Matthews S., Mueller C., Sains, M.C., Sederman A.J. Dynamic MR imaging of single- and two-phase flows. Chemical Engineering Research & Design. 84(A4):272-281 (2006)
  18. Lee W.P., Gundabala V.R., Akpa B.S., Johns M.L., Jeynes C., Routh A.F. Distribution of surfactants in latex films: A Rutherford backscattering study. Langmuir. 22(12):5314-5320 (2006).
  19. Akpa B.S., Mantle M.D., Sederman A.J., Gladden L.F. In situ 13C DEPT MRI as a tool to spatially resolve chemical conversion and selectivity of a heterogeneous catalytic reaction occurring in a fixed bed reactor. Chemical Communications. 21:2741-2743 (2005).

Book Chapters:

  1. Gladden L.F., Akpa B.S., Anadon L.D., Dunckley C.P., Lim M.H.M., Mantle M.D., Sederman A.J.  Magnetic resonance imaging: a new window on the catalyst operating in the reactor environment.    In ‘Turning Points in Solid-State, Materials and Surface Science.’ Harris K.D.M. and Edwards P.P. (Eds.) Royal Society of Chemistry, Cambridge UK (2008), 457-478.
  2. Gladden L.F., Akpa B.S., Mantle M.D., Sederman A.J.  In situ reaction imaging in fixed-bed reactors using MRI. In ‘NMR in Chemical Engineering.’ Stapf S. and Han S. (Eds.) Wiley-VCH, Germany (2006), 590-608.