Contact Information:

UIC – Department of Chemical Engineering, 810 S. Clinton, Chicago, IL 60607

Office: 206 SEO

Lab Website:  Laboratory for Product and Process Design

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Postdoctoral Research Associate Massachusetts Institute of Technology, 1994

Postdoctoral Fellow University of California at Berkeley, 1992

Ph.D. Chemical Engineering Vienna University of Technology (with highest distinction), 1992

Diploma Chemical Engineering Vienna University of Technology (with highest distinction), 1989

Fluid exchange in the brain: Elucidate transport mechanisms in the brain through aquaporin transmembrane proteins. Quantify intracellular regulatory mechanisms towards novel molecular treatment options of hydrocephalus.

Hydrocephalus: Develop micro-electronic devices including a ventricular volume sensor to improve treatment options for hydrocephalus patients.

Cerebral hemodynamics: Predict organ-wide blood flow patters in normal conditions and in diseases including ischemic stroke, arterio-venous malformations (AVM) and aneurysms.

Control of cerebral blood flow and metabolism: Investigate molecular mechanisms of neurovascular coupling using micro-imaging and computational methods. Measure blood flow in major cerebral blood vessels with in-vivo imaging modalities.

Virtual reality diagnostic and training for neurosurgeons: Develop novel fully immersed virtual reality applications for providing neurosurgeons and medical students with better diagnostic, planning and training options for neurovascular interventions.

Elected Editorial Board Member – Computers and Chemical Engineering, Premier Journal in Process Systems Engineering, 2012.

Best Poster Honorable Mention for Scientific Visualization, VisWeek 2012, Seattle, WA, 2012. (senior author).

Keynote Lecture, ESCAPE-22, Systems Biology and Healthcare Engineering, London, 2012.

First place in Kosaka award for basic science research, IARS, 2012. (senior author).

Best poster award in Regional Anesthesia Category – International Anesthesia.

Research Society 2012 (senior author).

2nd Place Mimics Innovation Award, Personalized gene-silencing therapies, 2012.

Keynote Lecture, 1st International Chemical Engineering Symposium, Tlaxcala, Mexico, 2011.

Keynote Lecture, ESCAPE-21, Biomedical Engineering, Chalkidiki, Greece, 2011.

Plenary Lecture, 8th International Conference on Chemical Engineering, Puebla, Mexico, 2011.

Editor, Chemical Engineering Research and Design, Subject: Process Systems Engineering, 2010.

AICHE CAST Directors Award, 2nd prize (honorable mention) in AIChE Student Poster competition, Salt Lake City, Utah, 2010. (corresponding author).

Keynote Lecture, Intl. Symposium on Process Systems Engineering, Salvador, Brazil, 2009.

Organizer Foundation Conference of Computer-Aided Process Design, FOCAPD 2009.

College of Engineering Teaching Award, 2009.

Best Paper Computers and Chemical Engineering Journal, 2008 (corresponding author).

Keynote Lecture, Medical Innovation Conference, Vienna, 2008.

Mimics Innovation Award, Innovative Medical Procedures, 2006.

Distinguished Lecture, Imperial College, 2005.

Mimics Innovation Runner Up Award, 2005.

Best Paper of the Conference Award, Cybernetics and Systems Research, 2004.

Best Paper of Symposium Award, Cybernetics and Systems Research, 2004.

College Faculty Research Award, 2004.

Faculty Scholar Award, 2003.

Inaugural Faculty Scholar Award, 2002.

Teaching Recognition Program Award, 2002.

Keynote Lecture, Annual International Meeting of the Austrian Society of Metallurgy, 2001.

Keynote Lecture, Japan Society for the Promotion of Science, Yokohama, 2000

Best Paper Award, Cybernetics and Systems Research, 1998.

Research Scholarship of the Austrian Chamber of Commerce, 1994.

Best doctoral dissertation of the Vienna University of Technology award and winner of the Hrabak Foundation Investigation Scholarship, 1992.

Mobility Scholarship of the Austrian Department of Science and Arts, 1990


  1. A. Linninger, I. Gould, T. Marinnan, C.-Y. Hsu, M. Chojecki, and A. Alaraj, “Cerebral Microcirculation and Oxygen Tension in the Human Secondary Cortex”, Annals of Biomedical Engineering, 2013
  2. E. Lueschen, I. Venugopal, J. Kanikunnel, T. Soni, A. Alaraj, and A. Linninger, “Intrathecal magnetic drug targeting using gold-coated magnetite nanoparticles in a human spine model”, Nanomedicine, 2012
  3. Y. Hsu, M. H.D.M. Hettiarachchi, D. Zhu and A. Linninger, “Frequency and magnitude of cerebrospinal fluid pulsations influence intrathecal drug distribution: Key factors for interpatient variability”, Anesthesia & Analgesia, 115 (2) , 386-394, 2012.
  4. S. Basati, B. Desai, A. Alaraj, F. Charbel, and A. Linninger, “Cerebrospinal fluid volume measurements in hydrocephalic rats”, Journal of Neurosurgery, (10), 347-354, 2012.
  5. C. Hall; A. Mošat, E. Lueshen, and A. Linninger, “Interspecies Scaling in Pharmacokinetics: A Novel Whole-Body
    Physiologically Based Modeling Framework to Discover Drug Biodistribution Mechanisms In Vivo”, Journal of Pharmaceutical Sciences, 101 (3), 1221–1241, 2012.
  6. A. Linninger, “Biomedical systems research – new perspectives opened by quantitative medical imaging”, Position paper inComp. Chem. Eng, 36, 1-9, 2012.
  7. O. Ivanchenko, O, N. Sindhwani, and A. Linninger, Exact Solution of the Diffusion-Convection Equation in Cylindrical Geometry, AICHE J, 58 (4), 1299-1302, 2012.
  8. J. Moon, S. Kim, and A. A. Linninger, “Integrated design and control under uncertainty: Embedded control optimization for plantwide processes”, Comp. Chem. Eng 35 (2011) 1718– 1724, 2011.
  9. H.D.M. Herriarachchi, Y. Hsu, T. Harris, and A.A. Linninger, “The Effect of Pulsatile Flow on Intrathecal Drug Delivery in the Spinal Canal”, A. Biom. Eng., 39(10), pp 2592-2602, 2011.
  10. R.D. Penn, S. Basati, B. Sweetman, X. Gou, A.A. Linninger, “Ventricular wall movements and cerebrospinal fluid flow in hydrocephalus”, J. Neurosurg., 115, pp 159-164, 2011.
  11. B. Sweetman, M. Xenos, L, Zitella, A.A. Linninger, “Three-dimensional Computational Prediction of Cerebrospinal Fluid Flow in the Human Brain”, Computer in Biology and Medicine, 41, pp 67-75, 2011.
  12. G. Ruiz, S. Kim, L. Moes, A.A. Linninger, “Rigorous synthesis and simulation of complex distillation networks”, AIChE Journal, 57(1), pp 136-148, 2011.
  13. S. Basati, T. Harris, A.A. Linninger, “Dynamic Brain Phantom for Intracranial Volume Measurements”, IEEE Transactions on Biomedical Engineering, 58(5), pp 1450-1455, 2011.
  14. N. Sindhwani, O. Ivanchenko, E. Lueshen, K. Prem, A.A. Linninger, “Methods for Determining Agent Concentration Profiles in Agarose Gel During Convection-Enhanced Delivery”, IEEE Transactions on Biomedical Engineering, 58(3), pp 626-632, 2011.
  15. B. Sweetman, and A.A. Linninger, “Cerebrospinal Fluid Flow Dynamics in the Central Nervous System”, A. Biom. Eng., 39(1), pp 484-496, 2011.
  16. O. Ivanchenko, N. Sindhwani, and A.A. Linninger, “Experimental Techniques for Studying Poroelasticity in Brain Phantom Gels Under High Flow Microinfusion”, J. of Biomechanical Eng., 132(5), pp 051008, 2010.
  17. D. Beneke, S. Kim, and A.A. Linninger, “Pinch Point Calculation and Its Implication on Robust Distillation Design”,Chinese Journal of Chemical Engineering, 19(6), pp 911-925, 2011.
  18. D. Beneke and A. Linninger, “Graphical design and analysis of thermally coupled sidestream columns using Column Profile Maps and Temperature Collocation”, AICHE J, 57 (9), 2406-2420, 2011.
  19. S. Kim, G. Ruiz, and A.A. Linninger, “Rigorous Separation Design. 1. Multicomponent Mixtures, Nonideal Mixtures, and Prefractionating Column Networks”, Industrial & Engineering Chemistry Reasearch, 49(14), pp 6499-6513, 2010.
  20. S. Kim and A.A. Linninger, “Rigorous Separation Design. 2. Network Design Solutions for Mixtures with Various Volatility Differences and Feed Compositions”, Industrial & Engineering Chemistry Reasearch, 49(18), pp 8670-8684, 2010.
  21. A. Linninger, M. Xenos, B. Sweetman, S. Ponkshe, X. Guo, and R. Penn. A mathematical model of blood, cerebrospinal fluid and brain dynamics. Journal of Mathematical Biology, 59(6): 729-759, 2009.
  22. A. Linninger, B. Sweetman and R. Penn. Normal and hydrocephalic brain dynamics; reduced cerebrospinal fluid reabsorption and ventricular enlargement, Annals of Biomedical Engineering. DOI: 10.1007/s10439-009-9691-4, 2009.
  23. G. Ruiz, S. Kim, J. Moon, L. Zhang, and A. Linninger, Design and optimization of energy efficient complex separation networks. Journal of Mathematical Biology, 59(6): 729-759, 2009.
  24. A. Linninger. Industry-wide energy saving by complex separation networks. Comp. Chem. Eng., 33 (12): 2018-2027, 2009
  25. R. Penn and A. Linninger, The Physics of Hydrocephalus-A Review, Pediatric Neurosurgery, 4 5:161-174, 2009.
  26. A. Linninger, S. Basati and R. Penn. An Impedance Sensor to Monitor and Control Cerebral Ventricular Volume. Medical Engineering and Physics, 31(7): p. 838-45, 2009.
  27. Moon, J., and Linninger, A.A., “ A Hybrid Sequential Niche Algorithm for Optimal Engineering Design with Solution Multiplicity”, Computers and Chemical Engineering, 33(7): 1261-1271, 2009.
  28. A. Linninger, M. Somayaji, X. Guo, T. Erickson, X. Guo and R. Penn. Computational Methods for Predicting Drug Transport in Anisotropic and Heterogeneous Brain Tissue, J of Biomechanics, 41: 2176-2187, 2008.
  29. K. Kulkarni, P. Larsen, and A. Linninger, Assessing Chronic Liver Toxicity Based on Relative Gene Expression Data,Journal of Theoretical Biology, 254: 308-318, 2008.
  30. A. Linninger, M.R. Somayaji, L. Zhang, M.S. Hariharan, and R. Penn. Rigorous Mathematical Modeling Techniques for Optimal Delivery of Macromolecules to the Brain, IEEE Transaction on Biomedical Engineering, 55 (9): 2303-2313, 2008.
  31. . Moon, K. Kulkarni, L. Zhang, and A. Linninger. Parallel Hybrid Algorithm for Process Flexibility Analysis, Industrial and Engineering Chemistry Research, 47, 8324-8436, 2008.
  32. K. Kulkarni, J. Moon, L. Zhang, A. Lucia, and A. Linninger. Multi-scale Modeling and Solution Multiplicity in Catalytic Pellet Reactors. Industrial and Engineering Chemistry Research, 47 (22): 8572-8581, 2008
  33. A. Lucia, R. Gattupalli, K. Kulkarni, and A. Linninger. A Barrier-Terrain Methodology for Global Optimization, Industrial and Engineering Chemistry Research, 47: 2666-2680, 2008.
  34. A. Abuhabsah, A. Linninger and P. Rousche. Apprenticeships in Scientific Research: Exploring Brain Functioning in a Research Lab and in a Seventh Grade Classroom. Spectrum – The Journal of the Illinois Science Teachers Association, 34 (1): 18-23, 2008
  35. A.A. Linninger, M.R. Somayaji, M. Mekarski, L. Zhang, “Prediction of convection-enhanced drug delivery to the human brain”, Journal of Theoretical Biology 250, pp 125-138,2008.
  36. M. Somayaji, M. Xenos, L. Zhang, M. Mekarski, A. Linninger. Systematic design of drug delivery therapies, Computers and Chemical Engineering, 32: 89–98, 2008.
  37. A. Malcolm, J. Polan, L. Zhang, B. Oguannaike, A.A. Linninger, “Integrating systems design and control using dynamic flexibility analysis”, AIChE Journal, 53 (8), pp 2048-2061, 2007.
  38. L. Zhang, K. Kulkarni, M.R. Somayaji, M. Xenos, A.A. Linninger, “Discovery of transport and reaction properties in distributed systems”, AIChE Journal, 53 (2), pp 381-396, 2007.
  39. A. Malcolm, L. Zhang, A.A. Linninger, “Optimal regulation for sustainable drug manufacturing”, International J. of Environment and Pollution,29 (1-3), pp 144-164, 2007.
  40. A.A. Linninger, M. Xenos, D. Zhu, M.R. Somayaji, R. Penn, “Cerebrospinal fluid flow in the normal and hydrocephalic human brain”, IEEE Transactions on Biomedical Engineering 54 (2), pp 291-302, 2006.
  41. L. Zhang, C. Xue, A. Malcolm, K. Kulkarni, A.A. Linninger, “Distributed system design under uncertainty”, Ind. Eng. Chem. Res. , 45 (25), pp 8252-8360, 2006.
  42. D. Zhu, M. Xenos, A.A. Linninger, R. Penn, ” Dynamics of lateral ventricle and cerebrospinal fluid in normal and hydrocephalic brains”, Journal of magnetic resonance imaging, 24, pp 756-770, 2006.
  43. K. Kulkarni, L. Zhang, A.A. Linninger, “Model and parameter uncertainty in distributed systems”, Ind. Eng. Chem. Res.,45 (23); 7832-7840, 2006.
  44. A. Malcolm, L. Zhang, A.A. Linninger, ” Design of environmental regulatory policies for sustainable emission reduction”,AIChE Journal, 52 (8), pp 2792-2804, 2006.
  45. L. Zhang, A.A. Linninger, “Towards computer-aided separation synthesis”, AIChE Journal, 52 (4), pp 1392-1409, 2006.
  46. W. Tang, L. Zhang, A.A. Linninger, R.Tranter, K. Brezinsky, “Solving kinetic inversion problems via a physically bounded Gauss-Newton (PGN) method”, Ind. Eng. Chem. Res., 44(10), pp 3626-3637, 2005.
  47. A.A. Linninger, C. Tsakiris, Zhu, M. Xenos, P. Roycewicz, Z. Danziger, R.Penn,”Pulsatile cerebrospinal fluid dynamics in the human brain”, IEEE Transactions on Biomedical Engineering, 52(4), pp 557-565, 2005.
  48. R.D. Penn, M.C, Lee, A.A. Linninger, K. Miesel, S.N. Lu, L. Stylos, “Pressure gradients in the brain: an experimental model of hydrocephalus”, J. Neurosurgery, pp 1069-1075, 2005.


  1. S. Chowdhry, H. Krendl, A.A. Linninger, “Symbolic numeric index analysis algorithm for differential algebraic equations”,Ind. Eng. Chem. Res., 43, pp 3886-3894, 2004.
  2. L. Zhang, A.A. Linninger, “Temperature collocation algorithm for fast and robust distillation design”, Ind. Eng. Chem. Res., 43, pp 3163-3182, 2004 .
  3. A. Chakraborty, A. Malcolm , A.A. Linninger, “Pharmaceuticals product-only design”, Proceedings of FOCAPD-2004 Conference Proceedings, pp 347-351, 2004.
  4. A. Chakraborty , A. Malcolm , R.D. Colberg, , A.A. Linninger , “Optimal waste reduction and investment planning under uncertainty”, Computers and Chemical Engineering, 28(7), pp 1145-1156, 2004.
  5. A. Chakraborty , K. Purkarthofer, A.A. Linninger, “Conceptual design of metallurgical processes – based on thermodynamic and economic insights”, Chemical Engineering Progress, 43, pp 625- 640, 2004.
  6. A. Chakraborty, A.A. Linninger, “Plant-wide waste management 2. Decision making under uncertainty”, Ind. Eng. Chem. Res., 42, pp 357- 369, 2003.
  7. A. Chakraborty, A.A. Linninger, “Plant-wide waste management. 3. Long term operation and investment planning under uncertainty”, Ind. Eng. Chem. Res., 42, pp 4772 – 4788, 2003.
  8. A. Chakraborty, A.A. Linninger,R.D. Colberg, “Optimal waste reduction and investment planning under uncertainty”,Proceedings of the FOCAPO-2003 Conference, 2003.
  9. A. Chakraborty, A.A. Linninger, “Plant-Wide waste management. 1. Synthesis and multi-objective design”, Ind. Eng. Chem. Res., 41 (18), pp 4591 – 4604, 2002.
  10. A.A. Linninger , “Metallurgical process design – A tribute to Douglas’s conceptual design approach”, Ind Eng. Chem. Res., 41(16), pp. 3797- 3805, 2002.
  11. A.A. Linninger, A. Chakraborty, G. Stephanopoulos, “Screening of recovery and treatment options for waste minimization”. In “Process design tools for the environment”, S. K. Sikdar, M. El-Halwagi (Eds), Taylor and Francis, London, 2001.
  12. A.A. Linninger, “Modeling and simulation of metallurgical processes”, BMH, Springer Verlag, 146 (9), pp 369-372, 2001.
  13. A.A. Linninger,A. Chakraborty, “Pharmaceutical waste management under uncertainty”, Comp. Chem. Eng., 25, pp 675-681, 2001.
  14. V. Bahl, A. A. Linninger, “Modeling of event-driven continuous-discrete processes”, Lecture notes in computer science 2034, Springer Verlag, pp 387- 402, ISBN 3-540-41866-0,  2001.
  15. S. Chowdhry, A. A. Linninger, “Automatic structure analysis of large scale differential algebraic systems”, Proc. IEEE instrumentation and measurement technology conference, Budapest, May 21 – 23, 2001. in press.
  16. A.A. Linninger, “Recent advances in process systems engineering”, Proc. IEEE Instrumentation and Measurement Technology Conference , Budapest, May 21- 23, 2001. in press.
  17. A. Chakraborty, A. A. Linninger, “Plant-wide waste management. 1. synthesis and multi-objective design”, Industrial and Engineering Chemistry Research, September 2001.
  18. A.A. Linninger, “Towards computer-aided model generation”, Keynote Lecture, Japan Society for the Promotion of Science (JSPS) International Workshop on Safety-Assured Operation and Concurrent Engineering, Sponsored by Japan Society for the Promotion of Science , Yokohama, Japan,December 3-5, 2000.
  19. A.A. Linninger, “Metamodeling – a novel approach for phenomena-oriented model generation”, AICHE Symposium Series, 96 (323), pp 462 – 465, 2000.
  20. A.A. Linninger, A. Chakraborty, R. Colberg, “Planning of waste reduction strategies under uncertainty”, Comp. Chem. Eng., 24, 1043 – 1048, 2000.
  21. A.A Linninger, S. Chowdhry, V. Bahl, H. Krendl, H. Pinger, “A systems approach to mathematical modeling of industrial processes”, Comp. Chem. Eng., 24, 591 – 598, 2000.
  22. V. Bahl, A. A. Linninger, “Hybrid simulation of continuous discrete systems”, Proc. ESCAPE-10, Florence, pp 163 – 168, S. Pierucci (Ed.),Elsevier, Amsterdam, 2000.
  23. A.A. Linninger, A. Chakraborty, “Decision-making for batch manufacturing sites under uncertainty”, Proc. ESCAPE-10, Florence , pp 901 – 906, S. Pierucci (Ed.), Elsevier, 2000.
  24. S. Chowdhry, A.A. Linninger, “Model simplification for dynamic systems”, Proceeding in the 19th IASTED International Conference on Modeling Identification and Control, Innsbruck, Austria, Feb. 14 – 17, pp.452 – 456, 2000.
  25. V. Bahl, S. Chowdhry,A.A. Linninger, “A high level language for hybrid systems”, Proceeding in the 19th IASTED International Conference on Modeling Identification and Control, Innsbruck, Austria, Feb. 14 – 17, pp. 608 – 614. 2000.
  26. A.A. Linninger, A. Chakraborty, “Design and analysis of optimal waste treatment policies”, AICHE Symposium Series, 96 (323), pp 355 – 359, 2000.
  27. G. Stephanopoulos, S. Ali, A.A. Linninger, E. Salomone, “Batch process development: challenging traditional approaches”,AICHE Symposium Series, 96 (323), pp 46 – 57, 2000.
  28. A.A. Linninger, H. Krendl, “TechTool – Computer-aided generation of process models (Part 1 – A Generic Mathematical Language)”, Comp. Chem. Eng., 23, pp 703-706, 1999.
  29. A.A. Linninger, A. Chakraborty, “Plant-wide optimal waste management”, Comp. Chem. Eng., 23, pp 67-70, 1999.
  30. A.A. Linninger ,A. Chakraborty, “Synthesis and optimization of waste treatment flowsheets”, Comp. Chem. Eng., 23, pp 1415 – 1425, 1999.
  31. A.A. Linninger, V. Bahl, “Integrated chemical engineering & industrial outreach – A new approach to design and chemical engineering practice”, Proc. International conference on engineering education, Prague, Czech Republic, August, 1999.
  32. A. Chakraborty,A. A. Linninger, “Multi-objective Ddsign of batch operating procedures”, Paper 216p, AIChE Annual Meeting, Oct. 31-Nov. 5, Dallas, TX, 1999.
  33. A. Chakraborty, A. A. Linninger, “Design of waste treatment policies under uncertainty”, Paper 236b, AIChE Annual Meeting, Oct. 31-Nov. 5, Dallas, TX, 1999.
  34. A. Chakraborty, A.A. Linninger, “Systematic assessment of treatment policies for liquid wastes from pharmaceutical plants: a case study”, Paper 24c, AICHE Spring National Meeting, March 14-18, 1999, Houston, Texas.
  35. A. Chakraborty, A.A. Linninger, “Synthesis of treatment flowsheets for pharmaceutical wastes”, Paper 98c, AICHE Spring National Meeting, March 14-18, 1999, Houston, Texas.
  36. A.A. Linninger, V. Bahl, S. Chowhdry, H. Krendl,  “TechTool – A process model generation environment”, Proceeding in the 18th IASTED International Conference on Modeling Identification and Control ‘99, Innsbruck, Austria, Feb. 15 – 18, pp 370 – 373, 1999.
  37. G. Stephanopoulos, S. Ali, A.A. Linninger, E. Salomone, “Batch process development: from reactions to manufacturing systems”, Comp. Chem. Eng., 23, pp 975-984, 1999.
  38. S.Ali, A.A. Linninger, G. Stephanopoulos, ” Synthesis of batch processing schemes as synthesis of operating procedures: a means-ends analysis and non-monotonic planning approach”, paper 216c, AICHE Annual Meeting, Nov 15 – 20, Miami, Fl, 1998.
  39. A.A. Linninger, G. Stephanopoulos ,” A natural language approach for the design of batch operating procedures”,Informatica, Special issue on natural language processing and multi-agent systems, 22( 4), ISSN 0250-5596, 1998.
  40. A.A. Linninger, E. Salomone, S. Ali, E. Stephanopoulos, G. Stephanopoulos, “Pollution prevention for production systems of energetic materials”, Waste Management Journal, 17, No 2/3, pp 165 – 173, 1998.
  41. A.A. Linninger, “Computer-aided model generation”, Workshop with Voest Alpine industries, Linz, Austria, Aug. 10 – 14, 1998
  42. A.A. Linninger,Computer-aided evolutionary process development in adaptation and evolution in embedded information systems, H. Franke, B. Kleinjohann, J. Sztipanovics (Eds), Dagstuhl Seminar Report, 226, ISSN 0940-1121, 1998.
  43. A. Linninger, “A Phenonena-driven process model generation environment”, Conference for model integrated computing, Vanderbilt University, Nashville, TN, Aug 6 – 7, 1998.
  44. A.A. Linninger, ” A corporate-wide initiative for integrated computer-aided process engineering”, FOCAPO conference, Snowbird, Utah, July 5 – 10, 1998.
  45. A.A.Linninger, G. Stephanopoulos, “Cybernetics and systems” Proc. Of fourth European meeting on cybernetics and systems research , R. Trappl (Ed), Vol1, Vienna, Austria, 1998.
  46. C. Richardson, S. Sopher, R. Petak, A.A. Linninger,”Conceptual process design using symbolic and numerical computing techniques”, MapleTech, Special Issue on Maple in Industry, ISSN 1061-5733, Vol 5, No 2/3, p. 3 – 14, 1998.
  47. A.A. Linninger, H. Krendl, H. Pinger, “An initiative for integrated computer-aided process engineering”, AICHE Symposium Series , 94 (320), pp 494 – 500, 1998.
  48. A.A. Linninger, S. A. Ali, G. Stephanopoulos, “Knowledge-based validation and waste management of batch pharmaceutical process designs”, Comp. Chem. Eng., 20, pp 1431 – 1436, 1996.
  49. A.A. Linninger, M. Hofer, H. Krendl, H. Druckenthaner, H. P. Jörgl, “M-PROJECT – organizing problem representation and modeling of steady state and dynamic processes”, Comp. Chem. Eng., 20, pp 425 – 430, 1996.
  50. A. A. Linninger, E. Stephanopoulos, S. A. Ali, E. Salomone, J. Aumond, G. Stephanopoulos. “BatchDesign-Kit – a comprehensive computer-aided design framework for batch process development with ecological considerations”, Paper 146h, AICHE Annual Meeting, Chicago, IL, Nov, 1996.
  51. A. A. Linninger, E. Salomone, S. A. Ali, E. Stephanopoulos and G. Stephanopoulos. “Pollution prevention for production systems of energetic materials”, Conference for life-cycles of energetic materials, Williamsburg, VI, Oct. 1996.
  52. A. A. Linninger, and G. Stephanopoulos, “Computer-aided waste management of pharmaceutical wastes”, Paper 23a ,AIChE Meeting , New Orleans, LA, 1996.
  53. A. A. Linninger, “Automatic flowsheet generation for waste treatment”, Lecture at the University of Massachusetts, Amherst , 1996.
  54. A.A. Linninger, G. Stephanopoulos, “Life-cycle design (LCD) – reengineering the process design procedure” , Proc. 88th Annual Meeting Air&Waste Management Association, Paper 95-TA40A.02, San Antonio, TX, 1995.
  55. A.A. Linninger, M. Hofer, A. A. Patuzzi, “DynEAF – A dynamic modeling tool for integrated electric steelmaking”, Iron and Steel Engineer, 72, 43-53, 1995.
  56. A.A. Linninger, S. A. Ali, E. Stephanopoulos, C. Han, G. Stephanopoulos, “Generation and assessment of batch processes with ecological considerations”, Comp. Chem. Eng., 19, pp 7-13, 1995.
  57. A.A. Linninger, A. A. Patuzzi, “Modern technology and information management at the example of electric arc furnace design”,  Stahl und Eisen, 115, pp 93-101, 1995.
  58. A.A Linninger, G. Stephanopoulos, “Modern waste management using a technology assessment expert system”, Paper 26a,AIChE Meeting , Boston, 1995.
  59. A.A. Linninger, “Design and assessment of batch pharmaceutical processes”, Lecture presented at ETH Zuerich, 1995.
  60. A.A Linninger, S. A. Ali, E. Stephanopoulos, C. Han, G. Stephanopoulos, “Synthesis and assessment of batch processes for pollution prevention”, AIChE Symposium Series, 90 (303), pp 46-53, 1994.
  61. A.A. Linninger, G. Stephanopoulos, “Batch design-kit – An expert system model for chemists and process developers”,Proc. Conference for Life-Cycles of Energetic Materials, pp 127-137, Del Mar, CA, 1994.