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PRODID:-//UIC
BEGIN:VEVENT
UID:2026091612493920140220T11000020140220T1200006aa9e7a398c4b@uic.edu
CATEGORIES:MEETING
STATUS:TENTATIVE
DTSTAMP:20190617T040016
DTSTART:20140220T110000
DTEND:20140220T120000
SUMMARY:Chris Macosko, University of Minnesota
DESCRIPTION:Abstract:  Nanoparticles of highly insoluble drugs can be created by flash nanoprecipitation, FNP. Turbulent mixing combined with a polymer stabilizer produces particles in the 100 nm size range, ideal for passive targeting of tumors and advantageous to increase solubility. We have used FNP to create nanoparticles containing a series of labile silicate prodrugs having customized hydrophobic character and hydrolysis rates. These are stabilized with poly(ethyleneglycol)-b-poly(lactic-co-glycolic acid) with well controlled molecular weights and narrow polydispersities. The particles are highly loaded and release studies indicate that hydrolysis occurs inside the particles with the drug released at rates controlled by the stereo-electronic character of the silicate. A MDMB231 (breast cancer) cell culture assay with paclitaxel-silicate loaded particles demonstrated in vitro efficacy. In vivo studies on mouse models with MDMB231tumors will also be reported. | Event post: https://che.uic.edu/events?page_id=1152
LOCATION:CEB 218 810 South Clinton Street  Chicago IL 60612
CLASS:PRIVATE
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