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BEGIN:VEVENT
UID:2026091511482920141204T11000020141204T1200006aa9d94d09c87@uic.edu
CATEGORIES:MEETING
STATUS:TENTATIVE
DTSTAMP:20190617T035430
DTSTART:20141204T110000
DTEND:20141204T120000
SUMMARY:Princess U II Imoukhuede, UIUC
DESCRIPTION:Understanding Angiogenic Signaling Through Systems Biology  Abstract:  The directed control of microvascularization or angiogenesis remains a pressing need in both cardiovascular disease and cancer research: indeed, over 70 diseases are angiogenesis-related. My laboratory seeks to address this need: understanding how angiogenesis can be promoted and how it can be inhibited, using systems biology. We believe that advancements in the systems biology-angiogenesis space require a bimodal approach, necessitating innovation in both experiment and computation. Recent advances will be described including our qFlow cytometry profiling of individual-VEGFRs on endothelial cells, in vitro and endothelial cells isolated from mouse skeletal muscle under normal and ischemic conditions, ex vivo. We have also recently constructed computational models of endothelial, VEGFR dynamics, which detailed the roles of the different VEGFRs in angiogenic signaling. Altogether, we will show how the integration of experimental profiling with deterministic computational modeling will achieve our long term goals of sensing, modeling, predicting, and ultimately tuning angiogenic signaling.   | Event post: https://che.uic.edu/events?page_id=1148
LOCATION:218 CEB 810 S. Clinton Street  Chicago IL 60612
CLASS:PRIVATE
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