Dec 4 2014

Princess U II Imoukhuede, UIUC

December 4, 2014

11:00 AM - 12:00 PM


218 CEB


810 S. Clinton Street, Chicago, IL 60612

Understanding Angiogenic Signaling Through Systems Biology

The directed control of microvascularization or angiogenesis remains a pressing need in both cardiovascular disease and cancer research: indeed, over 70 diseases are angiogenesis-related. My laboratory seeks to address this need: understanding how angiogenesis can be promoted and how it can be inhibited, using systems biology. We believe that advancements in the systems biology-angiogenesis space require a bimodal approach, necessitating innovation in both experiment and computation. Recent advances will be described including our qFlow cytometry profiling of individual-VEGFRs on endothelial cells, in vitro and endothelial cells isolated from mouse skeletal muscle under normal and ischemic conditions, ex vivo. We have also recently constructed computational models of endothelial, VEGFR dynamics, which detailed the roles of the different VEGFRs in angiogenic signaling. Altogether, we will show how the integration of experimental profiling with deterministic computational modeling will achieve our long term goals of sensing, modeling, predicting, and ultimately tuning angiogenic signaling.


UIC Chemical Engineering

Date posted

Jun 17, 2019

Date updated

Jun 17, 2019