Efie Kokkoli, University of Minnesota
February 12, 2015
12:00 AM - 12:00 AM
Design of Peptide- and Aptamer-Amphiphiles for Targeted Drug Delivery and Tissue Engineering
Self-assembly of biological molecules is an attractive method for engineering supramolecular biomaterials for different applications. I will discuss the design of a fibronectin-mimetic peptide-amphiphile and how we have used it to functionalize nanoparticles (stealth liposomes and polymersomes) for the targeted delivery of different therapeutics, both in vitro and in vivo. This fibronectin-mimetic peptide has also been used in our lab for the design of hydrogels, as tissue engineering scaffolds, for the entrapment of cells. Finally, I will introduce a new class of amphiphilic molecules, DNA-amphiphiles, that depending on the building blocks used for their design they can self-assemble into supramolecular nanostructures with non-spherical geometries, which is an area of great interest in DNA nanotechnology.
Date posted
Jun 17, 2019
Date updated
Jun 17, 2019