Feb 20 2014

Chris Macosko, University of Minnesota

February 20, 2014

11:00 AM - 12:00 PM


CEB 218


810 South Clinton Street, Chicago, IL 60612

Nanoparticles of highly insoluble drugs can be created by flash nanoprecipitation, FNP. Turbulent mixing combined with a polymer stabilizer produces particles in the 100 nm size range, ideal for passive targeting of tumors and advantageous to increase solubility. We have used FNP to create nanoparticles containing a series of labile silicate prodrugs having customized hydrophobic character and hydrolysis rates. These are stabilized with poly(ethyleneglycol)-b-poly(lactic-co-glycolic acid) with well controlled molecular weights and narrow polydispersities. The particles are highly loaded and release studies indicate that hydrolysis occurs inside the particles with the drug released at rates controlled by the stereo-electronic character of the silicate. A MDMB231 (breast cancer) cell culture assay with paclitaxel-silicate loaded particles demonstrated in vitro efficacy. In vivo studies on mouse models with MDMB231tumors will also be reported.


UIC Chemical Engineering

Date posted

Jun 17, 2019

Date updated

Jun 17, 2019